![]() ![]() In: Hatcher RA, Trussell J, Stewart F, Cates W, Stewart GK, Kowal D, Guest F, Contraceptive Technology: Seventeenth Revised Edition. Source: Trussell, J, Contraceptive Efficacy. Lactational Amenorrhea Method: LAM is a highly effective, temporary method of contraception. Emergency Contraceptive Pills: Treatment initiated within 72 hours after unprotected intercourse reduces the risk of pregnancy by at least 75%. Table 2: Percentage of Women Experiencing an Unintended Pregnancy During the First Year of Typical Use and the First Year of Perfect Use of Contraception and the Percentage Continuing Use at the End of the First Year. The following table lists the pregnancy rates for users of all major methods of contraception. However, the typical failure rate is estimated to be closer to 5%, due to late or omitted pills. If used perfectly, the first-year failure rate for progestin-only oral contraceptives is 0.5%. Progestin-only oral contraceptives are indicated for the prevention of pregnancy.Ģ. The mean terminal elimination half-life of norethindrone following single dose administration of norethindrone tablet is approximately 8 hours.ġ. Norethindrone is excreted in both urine and feces, primarily as metabolites. The majority of metabolites in the circulation are sulfate, with glucuronides accounting for most of the urinary metabolites.Įxcretion: Plasma clearance rate for norethindrone has been estimated to be approximately 600 L/day. Metabolism: Norethindrone undergoes extensive biotransformation, primarily via reduction, followed by sulfate and glucuronide conjugation less than 5% of a norethindrone dose is excreted unchanged greater than 50% and 20 to 40% of a dose is excreted in urine and feces, respectively. Volume of distribution of norethindrone is approximately 4 L/kg. The food effect on the rate and extent of norethindrone absorption after norethindrone tablets administration have not been evaluated.ĭistribution: Following oral administration, norethindrone is 36% bound to sex hormone binding globulin (SHBG) and 61% bound to albumin. Table 1: Mean ± SD Pharmacokinetic Parameters Following Single Dose Administration of Norethindrone Tablets in 12 Healthy Female Subjects Under Fasting Conditions Table 1 provides summary statistics of the pharmacokinetic parameters associated with single dose norethindrone tablets administration. ![]() The mean (SD) C avg was 885 (250) pg/mL, however, the mean concentration at 24 hrs was 130 (47) pg/mL. The mean (SD) C max was 4816.8 (1532.6) pg/mL and generally occurred within 1 hour (mean) of tablet administration, ranging from 0.5 to 2 hours. Peak plasma concentrations occur approximately 1 hour after administration (mean T max 1.2 hours). ![]()
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